Science

Photo-crosslinked biomaterials platform enables optimized formulation and delivery of advanced therapeutics such as cell and gene therapy

Inspired by Natural Materials

The GelMEDIX platform utilizes chemically modified natural polymers, such as gelatin, to create a hydrogel that mimics the material properties of natural tissue.

Crosslinking with White Light

One minute of exposure to focused white light turns the material from its liquid form into a soft solid.

Compatibility with Advanced Therapies

The combination of natural polymers and safe white light uniquely enables the formulation of advance therapeutics, cell and gene therapies, for improved delivery.

GMX-101

The next generation of retinal pigment epithelial (RPE) cell therapy for treating geographic atrophy

1) Stem cell-derived RPE are combined with unique hydrogel precursor in a standard syringe

2) GMX-101 is injected in the subretinal space, optimizing cell localization, viability, and engraftment

3) The hydrogel degrades quickly, allowing the cells to regenerate the proper retinal structure

Publications and Presentations

Improving RPE cell therapy with in situ forming hydrogel in porcine model

ARVO Annual Meeting Abstract 2023

In situ forming hydrogel improves RPE cell transplantation in a porcine model

ARVO Annual Meeting Abstract 2024

In situ forming hydrogel improves RPE cell transplantation in NaIO3-induced structural retinal degeneration in a rabbit model of geographic atrophy

ARVO Annual Meeting Abstract 2025